Werkstoffsimulation

Digital Health / Digitale Gesundheit – Mechanistic Digital Twins for Medicine

The CMM Lab develops physics-informed, mechanistic digital twins that link measurable physical phenomena—such as forces, deformation, wave propagation, and transport processes—with biological response. The lab’s work enables predictive and interpretable computational models for medical applications, complementing data-driven approaches with models grounded in first principles, verification, and experimental validation.

Key research directions include:

• Cardiovascular mechanics and medical devices: computational and experimentally informed analysis of patient- and geometry-specific vascular implants, including stents, with explicit consideration of tissue–structure interaction, manufacturing-induced variability, and mechanical performance under physiological loading.
• Mechanobiology and disease modeling: multiscale coupling of tissue mechanics with biological processes to support mechanistic understanding of disease progression and therapy response.
• Virus and cell mechanics: physics-based inference of mechanical properties from nano-indentation experiments and multiscale simulations, demonstrating how mechanical characterization can inform biological function and response to external physical stimuli.

These activities position the CMM Lab at the interface of computational mechanics, bioengineering, and digital medicine, spanning women’s health, cardiovascular systems, and mechanobiological processes.